Double-blind crossoer clinical trial of pyridinolcarbamate in peripheral arterial disease (arteriosclerosis obliterans).

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Double-blind crossoer clinical trial of pyridinolcarbamate in peripheral arterial disease (arteriosclerosis obliterans).

A double-blind crossover clinical trial of pyridinolcarbamate, a bradykinin antagonist, was carried out in 33 men with peripheral vascular disease causing intermittent claudication. Results in 25 men are reported. Peripheral circulation was assessed by measurement ofwork done before claudication in a step test, claudication point, and measurement of cal bloodflow by venous occlusion plethysmogr...

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Treatment of atherosclerosis obliterans with pyridinolcarbamate.

閉塞性動脈硬化症の薬物療法はじゆ うらい比較 的至難なものと考えられてお り,主 として血管拡 張薬が使用 されてきているが,理 論的にはその効 果 も疑問視されている.本 症の主観的症状は四肢 の知覚異常,間歇 性跛行などの症状で始まること が多いが,進 行して皮膚色調の変化,さ らに潰瘍 形成,感 染,壊 疽な どを起こすようになれば,交 感神経切除術,患 部の切断などの外科的処置を行 なわなければならないようにな り,こ の病気の予 後は全 く悲観的である.今 回本症 の75例 にpyri dinolcarbamate治 療を試みて比較的良好な治療成 績が得られたと思われるので,そ の成績について 報告する. 方 法 対 象 は 東 京 医 科 歯 科 大 学 第 三 内 科 の患者 で,総 数75例(男70,女5,年 令24~72才,平 均48.0±1.5 才.,発 病 よ ...

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ژورنال

عنوان ژورنال: Heart

سال: 1973

ISSN: 1355-6037

DOI: 10.1136/hrt.35.2.211